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Indulge in the heartwarming flavors of the South with our comforting recipe for Southern Mac and Cheese. This classic dish combines al dente macaroni with a decadent blend of mozzarella, sharp cheddar, and a hint of Cajun seasoning for a flavorful twist. Imagine the bubbling cheese aroma filling your kitchen, reminiscent of family gatherings and cherished memories.
Crafted with simple pantry staples, this Southern Mac and Cheese is a beloved family favorite that satisfies both kids and adults alike. The creamy texture and crispy golden topping make every bite a delight. Whether it’s a cozy weeknight dinner or a special occasion, this dish is sure to bring joy to the table. Embrace the tradition of Southern hospitality with this timeless recipe that promises to warm your heart and soul.
Quick Benefits
- Incredibly creamy texture with the perfect cheese blend
- Simple pantry ingredients you likely already have
- Family-friendly dish that satisfies both kids and adults
- Makes delicious leftovers that reheat beautifully
Why You’ll Love This Savory Southern Baked Macaroni and Cheese Recipe
- Creamy and Indulgent: The blend of mozzarella and sharp cheddar creates a velvety, cheesy sauce that coats every bite of macaroni beautifully.
- Family-Friendly Comfort Food: A dish that satisfies both young and old, perfect for family dinners or gatherings.
- Leftovers Done Right: Reheats beautifully, maintaining its creamy texture even after a few days in the refrigerator.
- Simple Pantry Ingredients: You likely have most of the ingredients on hand, making it an easy go-to recipe.
- Customizable and Versatile: Add your favorite ingredients like bacon, jalapeños, or chicken to make it your own.
- Freezes Well: Ideal for meal prep or making ahead for busy days, it freezes for up to 3 months.
- Perfect for Potlucks: A crowd-pleaser that can be easily doubled to feed larger groups.
- Nostalgic Southern Flavor: A taste of classic Southern comfort with a modern twist from the Cajun seasoning.
- Expert Tips for Success: Grate your own cheese, follow heating instructions for a smooth sauce, and achieve the perfect texture every time.
- Heartwarming and Satisfying: A dish that warms your heart and leaves you wanting more, a new family tradition in the making.
Ingredients for Savory Southern Baked Macaroni and Cheese
- 1 teaspoon Cajun seasoning
- 2 tablespoons all-purpose or gluten-free flour
- 2 tablespoons unsalted butter
- 1 cup whole milk
- 3/4 cup mozzarella cheese, shredded
- 1 teaspoon onion powder
- 3/4 cup sharp cheddar cheese, shredded
- 12 ounces evaporated milk
- 1/2 teaspoon black pepper
- 1 tablespoon garlic powder
- 1/2 teaspoon sea salt
- Additional cheese, for garnish
- 8 ounces macaroni, cooked and drained
Pro Tips for Savory Southern Baked Macaroni and Cheese
For the perfect Southern Mac and Cheese, aim for a creamy texture by grating your own mozzarella and sharp cheddar cheese. This will result in a smoother sauce compared to pre-shredded cheese. Also, to achieve that irresistible crispy top layer, try broiling the dish for the final 1 to 2 minutes, being careful not to burn it.
When reheating leftovers, maintain the creamy texture by adding a splash of milk before reheating in the oven at 325°F or microwaving with a damp paper towel covering the bowl. Let the mac and cheese rest for 5 minutes after baking to allow it to set properly. These tips will ensure that your dish tastes just as delicious as when freshly made, making it ideal for meal prep or planned leftovers.
How to Make Savory Southern Baked Macaroni and Cheese
Step 1: Step 01
Prepare macaroni according to package directions. Drain and set aside. Coat a 10.5×7.5-inch baking dish with nonstick spray. Preheat oven to 375°F (190°C).
Step 2: Step 02
In a large skillet over medium heat, melt butter. Whisk in flour until a thick slurry forms.
Step 3: Step 03
Combine whole milk, evaporated milk, onion powder, garlic powder, sea salt, black pepper, and Cajun seasoning in the skillet. Simmer lightly for 2 minutes, stirring often, until slightly thickened.
Step 4: Step 04
Add mozzarella and sharp cheddar cheese to the skillet. Stir constantly until the mixture thickens and becomes creamy. Remove from heat.
Step 5: Step 05
Mix the cooked macaroni into the skillet until well coated with the cheese sauce.
Step 6: Step 06
Transfer the macaroni mixture into the baking dish, sprinkle with extra cheese, and bake for 18-20 minutes until cheese is melted and edges are bubbly.
Step 7: Step 07
Take the dish out of the oven and allow it to sit for 5 minutes before serving.
Storage Tips
After preparing the Southern Mac and Cheese, store any leftovers in an airtight container in the refrigerator. This dish can be kept for up to 4 days, and when ready to reheat, add a splash of milk before covering with foil and placing it in a 325°F oven for about 15 minutes. Alternatively, for individual portions, microwave with a damp paper towel covering the bowl to help maintain moisture. The creamy texture of the mac and cheese holds up well even after reheating, making it a convenient option for meal prep or planned leftovers.
For longer storage, this dish can also be frozen for up to 3 months. Allow it to cool completely before transferring to a freezer-safe container or bag. When you’re ready to enjoy it, thaw the mac and cheese overnight in the refrigerator before reheating as usual. Remember to handle the dish gently to preserve its creamy interior and golden top. Whether you’re making this recipe for a comforting family meal or preparing it for a potluck, these storage tips will help you enjoy the delicious flavors of Southern Mac and Cheese anytime you crave it.
Ingredient Substitutions
For those looking to customize the flavor profile, consider swapping out the Cajun seasoning for a different spice blend such as Italian seasoning or smoked paprika. This simple change can give the dish a whole new dimension without straying too far from the classic comfort of Southern mac and cheese.
If you prefer a sharper cheese flavor, you can replace the mozzarella with a cheese like Gruyère or fontina, which will still provide a creamy texture but with a more pronounced taste. Similarly, if you want a more intense cheesy punch, swap out the sharp cheddar for a cheese like aged gouda or even blue cheese for a bold twist on this traditional dish. These substitutions allow you to tailor the mac and cheese to your personal preferences while maintaining its comforting essence.
Serving Suggestions
For a creative twist on serving this Southern Mac and Cheese, try turning it into a Mac and Cheese Bar at your next gathering. Set out various toppings like crispy bacon bits, sautéed jalapeños, diced roasted red peppers, and even shredded rotisserie chicken or steamed broccoli florets for guests to customize their own bowls of mac and cheese. This interactive and customizable setup adds a fun and personalized touch to the classic comfort food dish.
To elevate the presentation of this creamy and cheesy mac and cheese, consider serving it in individual mini cast-iron skillets or ramekins. Top each portion with a sprinkle of extra shredded cheese before baking to create a golden and bubbly crust. This individual serving style not only looks charming but also ensures that everyone gets their fair share of that irresistible cheesy pull.
FAQs for Savory Southern Baked Macaroni and Cheese
Can I use different types of cheese in this recipe?
Mozzarella and sharp cheddar are recommended for their creamy texture and bold flavor. Feel free to experiment with other cheeses like gouda or Monterey jack for different tastes.
Can I make this recipe gluten-free?
Yes! Substitute regular flour with gluten-free flour when making the cheese sauce, and use gluten-free macaroni.
How can I ensure a smooth consistency for the cheese sauce?
Whisk continuously while cooking over medium heat, and avoid overheating the milk or cheese to maintain a smooth consistency.
Can I prepare this dish ahead of time?
You can assemble the dish ahead of time, cover it, and refrigerate it. When ready to serve, bake it as instructed.
Conclusion
As you take your first bite of this indulgent Southern Mac and Cheese, you’ll be transported to a place of warmth and comfort, reminiscent of cherished family gatherings and cozy evenings at home. The creamy texture, flavorful blend of cheeses, and subtle hint of Cajun seasoning all come together to create a dish that truly embodies the essence of Southern comfort food.
Whether you’re making this dish for a special occasion or simply craving a deliciously comforting meal, Southern Mac and Cheese is sure to delight your taste buds and warm your soul. So gather your loved ones, savor each cheesy bite, and bask in the joy of sharing a meal that brings people together in the most delightful way. Embrace the tradition, love, and flavors of the South with every mouthful of this classic dish.

Savory Southern Baked Macaroni and Cheese
Ingredients
- 1 teaspoon Cajun seasoning
- 2 tablespoons all-purpose or gluten-free flour
- 2 tablespoons unsalted butter
- 1 cup whole milk
- 3/4 cup mozzarella cheese, shredded
- 1 teaspoon onion powder
- 3/4 cup sharp cheddar cheese, shredded
- 12 ounces evaporated milk
- 1/2 teaspoon black pepper
- 1 tablespoon garlic powder
- 1/2 teaspoon sea salt
- Additional cheese, for garnish
- 8 ounces macaroni, cooked and drained
Instructions
-
Step 01: Prepare macaroni according to package directions. Drain and set aside. Coat a 10.5×7.5-inch baking dish with nonstick spray. Preheat oven to 375°F (190°C).
-
Step 02: In a large skillet over medium heat, melt butter. Whisk in flour until a thick slurry forms.
-
Step 03: Combine whole milk, evaporated milk, onion powder, garlic powder, sea salt, black pepper, and Cajun seasoning in the skillet. Simmer lightly for 2 minutes, stirring often, until slightly thickened.
-
Step 04: Add mozzarella and sharp cheddar cheese to the skillet. Stir constantly until the mixture thickens and becomes creamy. Remove from heat.
-
Step 05: Mix the cooked macaroni into the skillet until well coated with the cheese sauce.
-
Step 06: Transfer the macaroni mixture into the baking dish, sprinkle with extra cheese, and bake for 18-20 minutes until cheese is melted and edges are bubbly.
-
Step 07: Take the dish out of the oven and allow it to sit for 5 minutes before serving.








